解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Sumatriptan is a 5-HT1B/D receptor agonist of documented efficacy in relieving migraine and associated symptoms such as nausea and vomiting. In the past decade, several studies reported an important delay of gastric emptying induced by sumatriptan in healthy humans. The impact of this gastric motor effect of sumatript...
journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1006/phrs.2000.0766
更新日期:2001-03-01 00:00:00
abstract::Treatment of MC3T3E-1 osteoblast cultures with combined interferon- gamma(IFN- gamma), lipopolysaccharide (LPS) and tumor necrosis factor- alpha(TNF- alpha) induces expressions of inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), resulting in sustained releases of large amounts of nitric oxide and IL-6....
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.2000.0778
更新日期:2001-03-01 00:00:00
abstract::Flibanserin has been reported to be an agonist at 5-HT1A-receptors and an antagonist at 5-HT2A receptors, with higher affinity for 5-HT1A receptors. Despite the fact that less receptor occupation is required by full agonists than by antagonists to exert their effects, flibanserin was shown to exert 5-HT2A antagonism a...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.2000.0762
更新日期:2001-02-01 00:00:00
abstract::Bombycis corpus(BC) or Bombyx Batryticatus, a batryticated silkworm and white-stiff silkworm, is a drug consisting of the dried larva of silkworm, Mobyz mori L., dead and stiffened due to the infection of Beauveria (Bals.) Vuill. In the present study, we have examined the protective effect of the water extracts agains...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.2000.0746
更新日期:2001-01-01 00:00:00
abstract::The effects of the P(2)-purinoceptor antagonist pyridoxal-phosphate-6-azophenyl- 2('),4(')- disulphonic acid (PPADS), the nitric oxide (NO) synthase inhibitor N(G)-nitro- l -arginine (l -NOARG), the K(+)-channel blocker apamin, the pituitary adenylate cyclase activating peptide (PACAP) antagonist PACAP(6-38) and the s...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.2000.0742
更新日期:2001-01-01 00:00:00
abstract::Conjugated linoleic acid (CLA) is being sold as a panacea that has the capability of reducing or eliminating cancer, preventing heart disease, improving immune function, and altering body composition to treat obesity or build lean body mass. Unfortunately, there has been very little published human research on CLA. Th...
journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1006/phrs.2000.0735
更新日期:2000-12-01 00:00:00
abstract::We compared the protective abilities of Mangifera indica L. stem bark extract (Vimang) 50-250 mgkg(-1), mangiferin 50 mgkg(-1), vitamin C 100 mgkg(-1), vitamin E 100 mgkg(-1)and beta -carotene 50 mgkg(-1)against the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative damage in serum, liver, brain as well as i...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.2000.0727
更新日期:2000-12-01 00:00:00
abstract::The hepatoprotective effects of acetylbergenin were examined against D -galactosamine (GalN)-induced liver damage in rats, compared with that of bergenin reported previously. Acetylbergenin was synthesized from acetylation of bergenin, isolated from Mallotus japonicus, to increase lipophilic and physiological activiti...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.2000.0730
更新日期:2000-11-01 00:00:00
abstract::The pharmacological physiological effects of the endogenous cannabinomimetic (endocannabinoid) anandamide have been well characterized. Another endocannabinoid, 2-arachidonoyl-glycerol (2-AG), has been less-widely studied. 2-AG occurs in vertebrate and invertebrate tissues and binds to both cannabinoid receptors (CB1 ...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.2000.0702
更新日期:2000-10-01 00:00:00
abstract::We have shown previously that the antitumor drug, hydroxyurea (HU) is able to induce dose-dependent increases in plasma corticosterone levels in the rat. The drug was administered early in the morning, when the levels of circulating glucocorticoids are low in this species. Normally, in humans under physiological condi...
journal_title:Pharmacological research
pub_type: 临床试验,杂志文章
doi:10.1006/phrs.2000.0709
更新日期:2000-10-01 00:00:00
abstract::The influence of intracerebroventricular (i.c.v.) injections of (S)-3,5-dihydroxyphenyl-glycine (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors (mGluRs), on the activity of the central nervous system was examined in male rats. (S)-3,5-DHPG at doses of 25, 50 and 100 nmol significantly att...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.2000.0683
更新日期:2000-09-01 00:00:00
abstract::Experiments were designed to evaluate the mechanisms of propofol and adenosine in rat atrial muscle. Atria were suspended in the isolated organ bath system for isometric tension recording and response to propofol and adenosine were tested in the absence and presence of glibenclamide, N(G)-nitro-arginine-methyl-ester (...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.2000.0666
更新日期:2000-08-01 00:00:00
abstract::Reproductive dysfunction in the female diabetic rat is associated with impaired hypothalamic-hypophyseal system, anovulation, insufficiency of ovarian steroidogenesis and spontaneous failure of pregnancy. Formation of decidua, the highly modified endometrium of pregnancy and pseudopregnancy could only be achieved when...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.2000.0673
更新日期:2000-08-01 00:00:00
abstract::Rats were treated with furosemide at intraperitoneal doses of 10, 20, and 30 mg kg(-1)day(-1)for 21 days, and some indices of thiamin status (liver, blood and urine thiamin concentrations, erythrocyte transketolase (TK) activity, and thiamin pyrophosphate (TPP) effect, which refers to the increase in TK activity in a ...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0632
更新日期:2000-07-01 00:00:00
abstract::Cicletanine [(+/-)-C] is a racemic furopyridine derivative used as an antihypertensive agent. Pharmacokinetic and metabolic studies have shown that cicletanine is rapidly and almost fully metabolized into sulfo- and glucuro-conjugated metabolites. However, the stereoselective metabolism of cicletanine is not well-know...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.2000.0660
更新日期:2000-07-01 00:00:00
abstract::The isolated heart is deservedly one of the most popular experimental models in cardiovascular research, both in terms of cost and the quality and quantity of data it provides. However, it is a deceptively simple model, capable of throwing many problems in the path of the inexperienced or unwary perfuser. The followin...
journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1006/phrs.1999.0653
更新日期:2000-06-01 00:00:00
abstract::Antifertility activity of a triterpenoid glycoside, DSS, isolated from the root of Dalbergia saxatilis was investigated in female Wistar rats of breeding age. When administered by gastric intubation at a dose rate of 200 mg kg(-1)body weight at the premating period, conception was inhibited in 71.4% of the treated ani...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0615
更新日期:2000-05-01 00:00:00
abstract::The formation of reactive oxygen species (ROS) appears to play a significant role in many pathological states including cystic fibrosis and asthma. Although stimulated inflammatory cells represent a major source of oxygen metabolites and these cells are able to generate the potent oxidant hypochlorous acid (HOCl) effe...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0628
更新日期:2000-05-01 00:00:00
abstract::Pharmacokinetic of methyldopa (50 mg kg(-1)i.p.) was studied in anesthetized sham operated and sinoaortic denervated (SAD) rats by using the microdialysis technique. Vascular shunt probe was inserted into the carotid artery and concentric probe was placed in the striatum. Levels of methyldopa were measured by HPLC-EC....
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0610
更新日期:2000-04-01 00:00:00
abstract::We studied here the effect of a wide range of adenosine concentration and time of preincubation, on the histamine release induced in the guinea pig mast cells by different stimulus. Adenosine (10(-5)-10(-3)m) potentiated the histamine release induced by antigen in the guinea pig heart (isolated and dispersed tissue) a...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0589
更新日期:2000-03-01 00:00:00
abstract::Perfusion of all mammalian heart muscle except hamster with Ca(2+)-free Tyrode and thereafter reperfusion with normal Tyrode causes irreversible damage, the calcium paradox. Our study aims at deciphering the role of creatine kinase, high energy phosphates and Ca(2+)influx in the genesis of myocardial injury in the rat...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0595
更新日期:2000-03-01 00:00:00
abstract::One of the most serious side effects of the immunosuppressive agent, cyclosporin A (CsA), is drug-related hypertension. As it is generally accepted, the sympathetic nervous system may play an important role in the development or maintenance of this abnormal pathophysiological situation. This study is aimed at assessin...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0572
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:We examined the influence of diabetes mellitus (DM) on the healing of HCl-induced gastric lesions and the healing promoting effect of IGF-1 on these lesions. METHODS:Experiments were performed on rats injected with streptozotocin (STZ, 70 mg kg(-1), i.p.) 5 weeks prior to the experimental session. Diabetic ...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0581
更新日期:2000-02-01 00:00:00
abstract::Sixteen adult hypertensive patients of both sexes, classified as having 'medium' (total lipid profile 240-300 mg dl(-1)), and 'high' (total lipid profile >300 mg dl(-1)) baseline values, underwent serum lipids, lipoproteins and plasma fibrinolytic parameters evaluations after 3 months of cilnidipine treatment. Patient...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0558
更新日期:2000-01-01 00:00:00
abstract::The concentration of five lipid-soluble antioxidants (gamma- and alpha-tocopherol, lycopene, beta-carotene and ubiquinol-10) was measured in plasma and very low-density, low-density and high-density lipoproteins (VLDL, LDL and HDL) isolated from young healthy normo- cholesterolemic subjects. Alpha-tocopherol was the e...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0552
更新日期:2000-01-01 00:00:00
abstract::The present study was aimed at investigating the role of endogenous nitric oxide (NO) in regulating Na,K-ATPase activity in the kidney. The expression of alpha-1 and beta-1 subunits; and the enzymatic activity of Na,K-ATPase were determined in the kidney of rats treated with an NO synthase inhibitor, N(G)-nitro-L-argi...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0570
更新日期:2000-01-01 00:00:00
abstract::(+)-3-(3-Hydroxyphenyl)-N-(1-propyl)-piperidine (3-PPP; a sigma receptor ligand), administered at 30 mg kg-1, 30 min before the test, significantly decreased the electroconvulsive threshold in mice, being ineffective in lower doses. 3-PPP (20 mg kg-1) diminished the protective activity of diphenylhydantoin, phenobarbi...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0548
更新日期:1999-12-01 00:00:00
abstract::The presence of M(1)-M(4) receptors in guinea-pig gallbladder smooth muscle cells has been reported recently. The majority of these receptors are said to be of M(2) subtype. However, there are controversial reports about the functional muscarinic receptors that mediate contraction in this tissue. Similar to gallbladde...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0536
更新日期:1999-11-01 00:00:00
abstract::Digoxin, which has a very narrow therapeutic window, is one of the most commonly prescribed drugs in the treatment of congestive heart failure. In some cases of atrial fibrillation digoxin is used in combination with verapamil. Verapamil can increase the plasma concentration of digoxin up to 60-90%. So far the precise...
journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1006/phrs.1999.0535
更新日期:1999-10-01 00:00:00
abstract::The uridin-diphosphoglucuronyl-transferase (UDP-GT) is a membrane-bound enzyme responsible for glucuronidation of endogenous and exogenous compounds. This work established the UDP-GT activity and its lipid membrane microenvironment in two experimental models: acute paracetamol intoxication, and cholestasis followed by...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0530
更新日期:1999-10-01 00:00:00
abstract::Felbamate (FBM) is a relatively novel anticonvulsant agent which has been reported to exert its antiepileptic effects by blockade of the glycine recognition site on the N-methyl-D-aspartate subtype of glutamate receptor and potentiation at the gamma-aminobutyric acid (GABA) type A receptor. An increasing number of ant...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0511
更新日期:1999-09-01 00:00:00
abstract::Capsaicin at a concentration of 10(-7)m induced a significant increase in heart rate and increased coronary flow in isolated Langendorff-perfused guinea-pig hearts. This effect was completely blocked by 30 microm of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase. Additional incu...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0475
更新日期:1999-08-01 00:00:00
abstract::Hypercalcemia and hypercalciuria observed both in humans and in animals who were on long-term theophylline therapy, prompted us to investigate whether oral theophylline treatment at optimal doses causes any adverse side effects on bone metabolism in mild asthmatics. Therefore, serum osteocalcin (BGP) and total alkalin...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0486
更新日期:1999-08-01 00:00:00
abstract::The survey was carried out, between September 1995 and May 1996, in order to describe the prescriptive behaviour among Sicilian general practitioners (GPs) in choosing an empirical antibiotic regimen for LRTIs in adult patients and begin an educational process which involves the same GPs in decisions regarding their p...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1998.0484
更新日期:1999-07-01 00:00:00
abstract::Cardiac arrhythmia can be a serious complication during general anaesthesia of patients suffering from cardiac arrhythmias and using antiarrhythmic drugs. The aim of the present experiments was to establish the way in which lidocaine and verapamil influence haemodynamic parameters of rabbits after midazolam anaesthesi...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1998.0464
更新日期:1999-06-01 00:00:00
abstract::The rationale underlying therapeutic strategies designed to inhibit the action of endogenous sex hormones in malignant breast cells is provided by the demonstration of their involvement in supporting the development and growth of breast carcinoma. The surgical removal of steroid-secreting glands, in order to reduce th...
journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1006/phrs.1998.0437
更新日期:1999-05-01 00:00:00
abstract::Receptor concentrations for adrenaline, steroid hormones, PGF2alpha, LH and FSH were measured in the hypophysis and ovary of dairy cows with ovarian cysts and the results were compared with those of healthy animals. Significant modifications were found in all receptor concentrations, either between follicular and lute...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1998.0442
更新日期:1999-04-01 00:00:00
abstract::Cardiac intracellular Na+and Ca2+homeostasis is regulated by the concerted action of ion channels, pumps and exchangers. The Na+, K+-ATPase produces the electrochemical concentration gradient for Na+, which is the driving force for Ca2+removal from the cytosol via the Na+/Ca2+exchange. Reduction of this gradient by in...
journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1006/phrs.1998.0416
更新日期:1999-03-01 00:00:00
abstract::Biochemical evaluations of the effects of the sulfhydryl-containing angiotensin-converting enzyme inhibitor (captopril) on the nephrotoxicity induced by doxorubicin in normal rats were carried out. A single dose of doxorubicin (15 mg kg-1) which caused nephrotoxicity was manifested biochemically by the elevation of se...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1998.0432
更新日期:1999-03-01 00:00:00
abstract::Eltanolone is the lipid emulsion formulation, for intravenous use, of the steroid anaesthetic 5-beta-pregnanolone. We have screened this agent in malignant hyperthermia susceptible (MHS) Landrace swine to assess its potential to trigger the Malignant Hyperthermia (MH) syndrome in MHS subjects or to influence halothane...
journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1998.0415
更新日期:1999-02-01 00:00:00